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Targeting the Wnt signaling pathway to augment bone formation

✍ Scribed by Mohammad Shahnazari; Wei Yao; Maripat Corr; Nancy E. Lane

Book ID
107547007
Publisher
Current Science Inc.
Year
2008
Tongue
English
Weight
321 KB
Volume
6
Category
Article
ISSN
1544-1873

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Members of the Wnt family of secreted glycoproteins act as short-range signaling molecules in vertebrate embryogenesis. Previous work has shown that Wnt-4 is required for kidney development. Mice lacking functional Wnt-4 fail to form pretubular cell aggregates. Wnt-4 acts as an autoinducer of the me