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Targeting the Bcl-2 family for cancer therapy

โœ Scribed by Thomas, Shibu; Quinn, Bridget A; Das, Swadesh K; Dash, Rupesh; Emdad, Luni; Dasgupta, Santanu; Wang, Xiang-Yang; Dent, Paul; Reed, John C; Pellecchia, Maurizio; Sarkar, Devanand; Fisher, Paul B

Book ID
120383812
Publisher
Informa plc
Year
2012
Tongue
English
Weight
433 KB
Volume
17
Category
Article
ISSN
1472-8222

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## Abstract Apoptosis plays an important role in skin carcinogenesis. Bclโ€X~L~, an antiapoptotic Bclโ€2 family member, is a key regulator in the process. Aberrant expression of Bclโ€X~L~ allows cells carrying mutations to survive and propagate. Overexpression of Bclโ€X~L~ is correlated with tumor mali