✦ LIBER ✦

Targeting Bcl-XL for prevention and therapy of skin cancer

✍ Scribed by Jack Zhang; G. Tim Bowden

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 119 KB
Volume: 46
Category: Article
ISSN: 0899-1987
DOI: 10.1002/mc.20330

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✦ Synopsis

Abstract

Apoptosis plays an important role in skin carcinogenesis. Bcl‐X~L~, an antiapoptotic Bcl‐2 family member, is a key regulator in the process. Aberrant expression of Bcl‐X~L~ allows cells carrying mutations to survive and propagate. Overexpression of Bcl‐X~L~ is correlated with tumor malignancy and invasion. Importantly, deregulation of Bcl‐X~L~ confers drug resistance to chemotherapy. Therefore, targeting Bcl‐X~L~ in combination with conventional chemotherapy is a promising way to pursue cancer chemotherapy. Several compounds targeting Bcl‐X~L~ expression or function have shown their potential in chemoprevention and of chemotherapy of cancer. © 2007 Wiley‐Liss, Inc.

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