𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Molecular tools for targeted imaging and therapy of cancer

✍ Scribed by Claude F. Meares; A. J. Chmura; Molly S. Orton; Todd M. Corneillie; Paul A Whetstone

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
99 KB
Volume
16
Category
Article
ISSN
0952-3499

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✦ Synopsis

Abstract

Here we review an approach to the design and production of antibody/ligand pairs for use in cell targeting procedures, to achieve functional affinity far greater than avidin/biotin. Using fundamental chemical principles, we have developed antibody/ligand pairs that retain the binding specificity of the antibody, but do not dissociate. By eliminating the dissociation of the ligand from the antibody, we have made the affinity functionally infinite. This methodology is applicable to other biological binding pairs. Copyright Β© 2003 John Wiley & Sons, Ltd.

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