Therapeutic potential of antisense Bcl-2 as a chemosensitizer for cancer therapy
โ Scribed by Ryungsa Kim; Manabu Emi; Kazuaki Tanabe; Tetsuya Toge
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 143 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Background: The bcl-2 oncoprotein suppresses apoptosis and, when overexpressed in prostate cancer cells, makes these cells resistant to a variety of therapeutic agents, including hormonal ablation. therefore, bcl-2 provides a strategic target for the development of gene knockout therapies to tre
It has been reported that genes regulating apoptosis may play a role in tumoral angiogenesis. This study examined the relationship between tumour vascularization, a measure of tumour angiogenesis, and bcl-2 and p53 expression in operable non-small-cell lung cancer (NSCLC). The relationship between b
The bacterial enzyme cytosine deaminase (CD) catalyzes the conversion of 5-fluorocytosine (5-FC) to the lethal 5-fluorouracil (5-Fu) and so provides a useful system for selective killing of gene-modified mammalian tumor cells. Cloning of the CD gene from Escherichiu coli and expression in human tumo