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BCL-2 family antagonists for cancer therapy

✍ Scribed by Lessene, Guillaume; Czabotar, Peter E.; Colman, Peter M.


Book ID
109950628
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
841 KB
Volume
7
Category
Article
ISSN
1474-1776

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## Abstract A critical regulator of the apoptotic machinery is the Bcl‐2 family proteins whose over expression confers a protective effect on malignant cells against death signals of apoptosis. Cancer cells that are resistant to various anti‐cancer drugs and treatment regimen are found to over expr