𝔖 Bobbio Scriptorium
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Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy

✍ Scribed by Jason O'Neill; Michael Manion; Pam Schwartz; David M. Hockenbery

Book ID
113486580
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
285 KB
Volume
1705
Category
Article
ISSN
0304-419X

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## Abstract Apoptosis plays an important role in skin carcinogenesis. Bcl‐X~L~, an antiapoptotic Bcl‐2 family member, is a key regulator in the process. Aberrant expression of Bcl‐X~L~ allows cells carrying mutations to survive and propagate. Overexpression of Bcl‐X~L~ is correlated with tumor mali