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Targeting gene expression to tumor cells with loss of wild-type p53 function

โœ Scribed by Zhu, Jingde; Gao, Baomei; Zhao, Jiangqin; Balmain, Allan


Book ID
110017647
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
481 KB
Volume
7
Category
Article
ISSN
0929-1903

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A number of transgenic animal model systems have addressed the mechanistic role of p53 loss in tumor progression. However, many of these tumor models have analyzed p53 function in the context of other transgenes expressing activated oncogenes or defective tumor suppressor genes generated by gene tar