Wild-type p53 gene transfer is not detrimental to normal cells in vivo: implications for tumor gene therapy

Exogenous wt-p53 protein is active in tr

Exogenous wt-p53 protein is active in transformed cells but not in their non-transformed counterparts: implications for cancer gene therapy without tumor targeting

✍ Gabriella D'Orazi; Alessandra Marchetti; Marco Crescenzi; Sabrina Coen; Ada Sacc 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 320 KB 👁 2 views

## Background: Expression of exogenous wild-type p53 (wt-p53) protein in tumor cells can suppress the transformed phenotype whereas it does not apparently induce detrimental effects in non-transformed cells. this observation may provide a molecular basis for p53-mediated gene therapy of p53-sensiti