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Targeted in utero delivery of a retroviral vector for gene transfer in the rodent brain

✍ Scribed by Simon R. W. Stott; Deniz Kirik


Book ID
109025646
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
695 KB
Volume
24
Category
Article
ISSN
0953-816X

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## Abstract ## Background The use of retroviral vectors has shown an actual clinical benefit in a few inherited diseases. However, the occurrence of cases of leukemia after the X‐SCID gene therapy trial raised concerns about the safety of insertional mutagenesis inherent to the biology of the retr