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Strategies for CNS-directed gene delivery: in vivo gene transfer to the brain using SV40-derived vectors

โœ Scribed by Louboutin, J-P; Reyes, B A S; Agrawal, L; Van Bockstaele, E; Strayer, D S


Book ID
110039985
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
597 KB
Volume
14
Category
Article
ISSN
0969-7128

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## Abstract Lentivirus vectors are being investigated as gene delivery vehicles for cystic fibrosis airway gene therapy. Vesicular stomatitis virus G glycoprotein (VSVโ€G)โ€pseudotyped vectors transduce airway epithelia via receptors that are located predominantly on the basolateral surface of the ai