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Targeted gene delivery to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption

✍ Scribed by Qin Huang; Jinmu Deng; Feng Wang; Song Chen; Yingjiang Liu; Zhibiao Wang; Zhigang Wang; Yuan Cheng

Book ID: 113616906
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 805 KB
Volume: 233
Category: Article
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2011.10.027

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## Abstract The clinical application of chemotherapy to brain tumors has been severely limited because antitumor agents are typically unable to penetrate an intact blood‐brain barrier (BBB). Although doxorubicin (DOX) has been named as a strong candidate for chemotherapy of the central nervous syst