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Targeted delivery of antibodies through the blood–brain barrier by MRI-guided focused ultrasound

✍ Scribed by Manabu Kinoshita; Nathan McDannold; Ferenc A. Jolesz; Kullervo Hynynen

Book ID
118426370
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
620 KB
Volume
340
Category
Article
ISSN
0006-291X

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## Abstract The clinical application of chemotherapy to brain tumors has been severely limited because antitumor agents are typically unable to penetrate an intact blood‐brain barrier (BBB). Although doxorubicin (DOX) has been named as a strong candidate for chemotherapy of the central nervous syst