MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model
✍ Scribed by O'Reilly, Meaghan A.; Waspe, Adam C.; Chopra, Rajiv; Hynynen, Kullervo
- Book ID
- 120258400
- Publisher
- MyJoVE Corporation
- Year
- 2012
- Tongue
- English
- Weight
- 396 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1940-087X
- DOI
- 10.3791/3555
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## Abstract Focused ultrasound combined with an intravascular ultrasound contrast agent can induce transient disruption of the blood–brain barrier, and the blood–brain barrier disruption can be detected by contrast‐enhanced MRI. There is, however, no study investigating the ability of various MR me
## Abstract ## Purpose: To optimize the timing of contrast‐enhanced magnetic resonance imaging (MRI) that best indicates blood–brain barrier (BBB) disruption induced by focused ultrasound (FUS) along with an ultrasound contrast agent (UCA) and to verify that the contrast‐enhanced spin‐echo MRI seq