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Tantalum [18O]Water Target for the Production of [18F]Fluoride with High Reactivity for the Preparation of 2-Deoxy-2-[18F]Fluoro-D-Glucose

โœ Scribed by N Satyamurthy; Bernard Amarasekera; C.William Alvord; Jorge R Barrio; Michael E Phelps


Book ID
117732893
Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
136 KB
Volume
4
Category
Article
ISSN
1536-1632

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A combined study of the labelling methods of two important glucose-derivatives i.e. [18F]2-deoxy-2-fluoro-D-glucose ([laF]2-FDG) and [lSF]3-deoxy-3-fluoro-D-glucose ([18F]3-FDG) is described. Using [ISF]fluoride as reacting agent produced in a water target via the 180(p, n)'SF and ~60(3He, p)~SF rea

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The presence of 2-deoxy-2-['sF]fluoro-D-mannose (['sF]FDM) in 2-deoxy-2-['\*F]fluoro-o-glucose (['aF]FDG) prepared by the reaction of 3,4,6-tri-0-acetyi-D-glucal (TAG) with ['\*F]acetyl hypofluorite ([r\*F]CHsCOOF) or ['sF]Fr was quantified by radio HPLC analysis of reacetylated ['\*F]FDG. The solve

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[18F]Fluoride was produced via the 18O (p, n) 18F reaction using a low volume stainless steel 18O-water target in a small cyclotron. The average 18F production rate for 60 runs was about 720 microCi/microA-min. A typical bombardment time of 20 min produced 120 mCi of 18F-fluoride. [18F]2-Fluoro-2-de