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Taking polycation gene delivery systems from in vitro to in vivo

โœ Scribed by Alexander V Kabanov


Book ID
114402119
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
148 KB
Volume
2
Category
Article
ISSN
1461-5347

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Polycation-based DNA complexes for tumor
โœ Ralf Kircheis; Susanne Schรผller; Sylvia Brunner; Manfred Ogris; Karl-Heinz Heide ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 651 KB

Background Efยฎcient and target-speciยฎc in vivo gene delivery is a major challenge in gene therapy. Compared to cell culture application, in vivo gene delivery faces a variety of additional obstacles such as anatomical size constraints, interactions with biological ยฏuids and extracellular matrix, and