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Polycation gene delivery systems: escape from endosomes to cytosol

โœ Scribed by Yong Woo Cho; Jong-Duk Kim; Kinam Park


Book ID
111769328
Publisher
Pharmaceutical Press
Year
2003
Tongue
English
Weight
515 KB
Volume
55
Category
Article
ISSN
2042-7158

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Endosomal escape and nuclear localization are two barriers to gene delivery that need to be addressed in the design of new nonviral gene delivery vehicles. We have previously synthesized low-toxicity polyethylene glycol (PEG)-based vehicles with endosomal escape functionalities, but it was determine