In B cells the loci encoding immunoglobulin chains usually show allelic exclusion; a given B cell transcribes and translates only one productively rearranged allele of the heavy and light chain loci. This ensures that each B cell expresses only one antigen receptor. The loci encoding T-cell receptor
T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α- and β-genes
✍ Scribed by Blüthmann, Horst; Kisielow, Pawel; Uematsu, Yasushi; Malissen, Marie; Krimpenfort, Paul; Berns, Anton; von Boehmer, Harald; Steinmetz, Michael
- Book ID
- 109754833
- Publisher
- Nature Publishing Group
- Year
- 1988
- Tongue
- English
- Weight
- 521 KB
- Volume
- 334
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/334156a0
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