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T cell response to myelin basic protein before and after treatment with interferon beta in multiple sclerosis

✍ Scribed by Giovanni Ristori; Chiara Montesperelli; Claudio Gasperini; Luca Battistini; Giovanna Borsellino; Carla Buttinelli; Stefania Cannoni; Alessia Perna; Carlo Pozzilli; Marco Salvetti

Book ID
114138907
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
199 KB
Volume
99
Category
Article
ISSN
0165-5728

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In order to explore the T-cell repertoire to myelin basic protein (BP) of both multiple sclerosis (MS) patients and healthy subjects (HS), we raised BP reactive T-cell lines from blood mononuclear cells of eight MS patients and five HS. These lines were triggered in vitro by human BP. When analyzing

T cell response to myelin basic protein
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✍ Roland Liblau; Elisabeth Tournier-Lasserve; Jacqueline Maciazek; GΓ©rad Dumas; Od πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 388 KB

T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence