T cell responses to myelin basic protein in patients with spinal cord injury and multiple sclerosis
β Scribed by Kisoo Kil; Ying C.Q Zang; Deye Yang; Jon Markowski; Glenn S Fuoco; Gina C Vendetti; Victor M Rivera; Jingwu Z Zhang
- Book ID
- 114138864
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 173 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0165-5728
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Previous studies from our laboratory showed the development of circulating T lymphocytes sensitized to myelin basic protein (MBP) in guinea pigs challenged with MBP. Also, lymphocytes sensitized to MBP were found in patients with multiple sclerosis (MS). In this report, we describe the kinetics of M
In order to explore the T-cell repertoire to myelin basic protein (BP) of both multiple sclerosis (MS) patients and healthy subjects (HS), we raised BP reactive T-cell lines from blood mononuclear cells of eight MS patients and five HS. These lines were triggered in vitro by human BP. When analyzing
T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence