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Myelin basic protein T cell epitopes in patients with multiple sclerosis

✍ Scribed by M. Salvetti; C. Buttinelli; P. Fiori; L. Toma; C. Pozzilli; C. Fieschi

Book ID
119107938
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
76 KB
Volume
35
Category
Article
ISSN
0165-5728

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T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence

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Previous studies from our laboratory showed the development of circulating T lymphocytes sensitized to myelin basic protein (MBP) in guinea pigs challenged with MBP. Also, lymphocytes sensitized to MBP were found in patients with multiple sclerosis (MS). In this report, we describe the kinetics of M