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T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

✍ Scribed by Ota, Kohei; Matsui, Makoto; Milford, Edgar L.; Mackin, Glenn A.; Weiner, Howard L.; Hafler, David A.


Book ID
109764190
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
601 KB
Volume
346
Category
Article
ISSN
0028-0836

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T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence