The T-cell response to myelin basic protein in familial multiple sclerosis: Diversity of fine specificity, restricting elements, and T-cell receptor usage
β Scribed by Dr. Narendra Joshi; Koichiro Usuku; Stephen L. Hauser
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 920 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
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T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence
T-cell receptor (TCR) β€-chain usage in experimental autoimmune encephalomyelitis (EAE) seems to be much more heterogeneous than previously assumed even for a single autoantigen in an inbred animal strain. Owing to the lack of suitable antibodies, this has been demonstrated only at the RNA level so f