T-cell receptor Vβ genes repertoire in mice possible role in resistance and susceptibility to type II collagen-induced arthritis
✍ Scribed by Haqqi, Tariq M.; David, Chella S.
- Book ID
- 122990316
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 844 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0896-8411
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## Abstract H‐I and H‐II high antibody‐responder Biozzi mice, which express the H‐2^q^ permissive haplotype, were shown to be sensitive and refractory to collagen‐induced arthritis, respectively. To assess a possible role of T cell receptor (TcR) V~β~ gene deletion or polymorphism in the resistance
## Objective: To study the genes in the mouse background which predispose to the development of collagen-induced arthritis (cia). ## Methods: T cell receptor beta transgenic (tcrbetal) mice that have a t cell repertoire that predisposes to the development of cia were used. classic genetic studies