## Abstract An important event in the pathogenesis of the autoimmune disease multiple sclerosis (MS) is the recruitment of lymphocytes and inflammatory macrophages to the central nervous system (CNS). Recruitment requires adhesive interactions between the leukocytes and the microvascular endotheliu
T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis
β Scribed by Alessandra Franco; Scott Southwood; Thomas Arrhenius; Vijay K. Kuchroo; Howard M. Grey; Alessandro Sette; Glenn Y. Ishioka
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 739 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0014-2980
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Previous studies of experimental allergic encephalomyelitis (EAE) in the LER rat have suggested that amino acid differences present in the LER TCR Vp8.2 chain may be associated with disease resistance. We report here that LEW rats bred to express a Vp8.2 gene from DA rats, identical to that found in