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Analysis of T cell receptor β chains in the rat: I. Allelic polymorphism of Vβ8.2 is not a predisposing genetic factor in susceptibility to experimental allergic encephalomyelitis

✍ Scribed by D.P. Gold; K. Schroder; D.B. Mueller; D.B. Wilson

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 617 KB
Volume: 45
Category: Article
ISSN: 0360-4012
DOI: 10.1002/(sici)1097-4547(19960915)45:6<700::aid-jnr6>3.0.co;2-c

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✦ Synopsis

Previous studies of experimental allergic encephalomyelitis (EAE) in the LER rat have suggested that amino acid differences present in the LER TCR Vp8.2 chain may be associated with disease resistance. We report here that LEW rats bred to express a Vp8.2 gene from DA rats, identical to that found in LER, are susceptible to EAE induction. Furthermore, T cells infiltrating the spinal cord of diseased animals primarily utilized Vp8.2 and the associated AspSer CDR3 motif, typical of TCR VpS.2 chains expressed by pathogenic, anti-MBP responsive T cells in the LEW rat.

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