✦ LIBER ✦

T-cell-mediated cytotoxicity

✍ Scribed by Gideon Berke

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 895 KB
Volume: 3
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(91)90031-u

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✦ Synopsis

There are two competing theories to explain the mechanism(s) by which cytolytic T lymphocytes kill target cells: granule exocytosis of a pore-forming protein, and contact-induced internal disintegration. Accumulated evidence supports alternative pathways in lymphocytoxicity, possibly reflecting distinct effector functions expressed by different killer cells and cells at different stages of activation.

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