𝔖 Bobbio Scriptorium
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Human natural cell-mediated cytotoxicity

✍ Scribed by James T. Forbes; F. Anthony Greco; Robert K. Oldham

Publisher
Springer-Verlag
Year
1981
Tongue
English
Weight
611 KB
Volume
11
Category
Article
ISSN
0340-7004

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✦ Synopsis

The contribution of natural cell-mediated cytotoxicity (NCMC) to tumor-directed cytotoxicity is unknown. This study was undertaken to correlate changes in NCMC to a single target cell (K-562) with responses to therapy in patients with small cell carcinoma of the lung, resectable stage I non-small cell carcinoma of the lung, and stage I and H melanomas. Data from these studies suggested that these patients have depressed levels of NCMC to 1(-562 compared with a normal age-matched control population. However, NCMC levels appear to fluctuate with tumor burden, being highest in patients with large tumor masses and lowest in patients with no clinical evidence of tumor following a successful response to therapy.

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