Assessment of cell-mediated cytotoxicity

Cell-mediated cytotoxicity

✍ Margaret K. Taylor; J.John Cohen 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 786 KB

Progress is being made in determining how cytotoxic cells are activated, the way the lethal hit is delivered and the subsequent events in the target cell. Several factors cloud the issue, including the heterogeneity of cytotoxic cells, differences between fresh cells and cell lines, and the possibil

T-cell-mediated cytotoxicity

✍ Gideon Berke 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 895 KB

There are two competing theories to explain the mechanism(s) by which cytolytic T lymphocytes kill target cells: granule exocytosis of a pore-forming protein, and contact-induced internal disintegration. Accumulated evidence supports alternative pathways in lymphocytoxicity, possibly reflecting dist

Spontaneous cell-mediated cytotoxicity

✍ H. H. Peter; W. Heidenreich 📂 Article 📅 1980 🏛 Springer-Verlag 🌐 English ⚖ 362 KB

Human natural cell-mediated cytotoxicity

✍ James T. Forbes; G. D. Niblack; R. Fuchs; R. E. Richie; H. K. Johnson; Robert K. 📂 Article 📅 1981 🏛 Springer-Verlag 🌐 English ⚖ 646 KB

## Natural cell-mediated cytotoxicity has been shown to be age-dependent in both rats and mice. The present study was undertaken to study age-related levels of natural cytotoxicity in humans. Mononuclear peripheral blood cells from over 200 normal volunteers were co-incubated with 51Cr-labeled K-5

Human natural cell-mediated cytotoxicity

✍ James T. Forbes; F. Anthony Greco; Robert K. Oldham 📂 Article 📅 1981 🏛 Springer-Verlag 🌐 English ⚖ 611 KB

The contribution of natural cell-mediated cytotoxicity (NCMC) to tumor-directed cytotoxicity is unknown. This study was undertaken to correlate changes in NCMC to a single target cell (K-562) with responses to therapy in patients with small cell carcinoma of the lung, resectable stage I non-small ce

Cell-mediated cytotoxic mechanisms

✍ Margaret K.T. Squier; J. John Cohen 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 841 KB