T cell development: Lead role for BCL-6 in TFH cell development
โ Scribed by Bell, Elaine
- Book ID
- 109956181
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 124 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1474-1741
- DOI
- 10.1038/nri2626
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๐ SIMILAR VOLUMES
The role of self-peptides in influencing the development of the T-cell repertoire has been the focus of recent studies. The findings suggest that the recognition of self-peptides bound to MHC proteins in the thymus is part of the thymic self-recognition process that results in selective maturation,
BCL-6 is an important regulator of the immune system. It is required for GC formation and T cell dependent antibody responses. Mice deficient in BCL-6 fail to form GC and mount reduced levels of T cell-dependent antibody responses. BCL-6 (-/-) mice, in addition, develop a massive inflammatory respon