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T cell development: Lead role for BCL-6 in TFH cell development

โœ Scribed by Bell, Elaine


Book ID
109956181
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
124 KB
Volume
9
Category
Article
ISSN
1474-1741

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BCL-6 is an important regulator of the immune system. It is required for GC formation and T cell dependent antibody responses. Mice deficient in BCL-6 fail to form GC and mount reduced levels of T cell-dependent antibody responses. BCL-6 (-/-) mice, in addition, develop a massive inflammatory respon