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A role for a pre-T-cell receptor in T-cell development

✍ Scribed by Marcus Groettrup; Harald von Boehmer


Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
683 KB
Volume
14
Category
Article
ISSN
0167-5699

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Most natural killer T (NKT) cells express a highly skewed Β§ g TCR repertoire, consisting of an invariant V Β§ 14-J Β§ 281 chain paired preferentially with a polyclonal V g 8.2 chain. This repertoire is positively selected by the monomorphic CD1d molecule expressed on cells of hematopoietic origin. The