Most natural killer T (NKT) cells express a highly skewed § g TCR repertoire, consisting of an invariant V § 14-J § 281 chain paired preferentially with a polyclonal V g 8.2 chain. This repertoire is positively selected by the monomorphic CD1d molecule expressed on cells of hematopoietic origin. The
MHC-restricted T cell receptor signaling is required for αβ TCR replacement of the pre T cell receptor
✍ Scribed by Andrew L. Croxford; Özlem Akilli-Ozturk; Frederic Rieux-Laucat; Irmgard Förster; Ari Waisman; Thorsten Buch
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 287 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The cytoplasmic tail of the T cell receptor < chain is required for signaling via CD26 The protease dipeptidylpeptidase IV (CD26) provides an alternative activation pathway for T lymphocytes and is involved in several aspects of Tcell function. Activation via CD26 requires the expression of the T c
## Abstract Ryanodine receptors (RyR) are involved in regulating intracellular Ca^++^ mobilization in T lymphocytes. However, the importance of RyR signaling during T cell activation has not yet been determined. In this study, we have used the RyR‐selective antagonists, ruthenium red and dantrolene
## Abstract Antigen stimulation through the T cell receptor (TCR) induces phosphorylation of the associated CD3 γδσ‐ and ζ‐chain cytoplasmic tails. These events lead to the induction of the intracellular signaling pathways with concomitant receptor down‐regulation. The TCR is down‐regulated from th
Identification of genetic structure and diversity of T-cell receptor (TCR)a and p genes for cytotoxic T lymphocytes (CTLs) infiltrating human cancers is important for the better understanding of molecular mechanisms of host defense at tumor sites. cDNAs of TCRu and p genes of 22 different melanoma-s