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The cytoplasmic tail of the T cell receptor ζ chain is required for signaling via CD26

✍ Scribed by Hans-Willi Mittrücker; Christiane Steeg; Bernard Malissen; Bernhard Fleischer

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
346 KB
Volume
25
Category
Article
ISSN
0014-2980

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✦ Synopsis

The cytoplasmic tail of the T cell receptor < chain is required for signaling via CD26

The protease dipeptidylpeptidase IV (CD26) provides an alternative activation pathway for T lymphocytes and is involved in several aspects of Tcell function. Activation via CD26 requires the expression of the T cell receptor (TcR)/CD3 complex. Here we have investigated the role of the TcR <chain for Tcell activation via CD26. T cell hybridomas expressing TcR with various deletions in the CD3 5 chain were transfected with a CD26 cDNA and the response of the transfected cells to anti-CD26 monoclonal antibodies was tested. Our data show that the L chain is essential and that at least oneYXXL motif in the cytoplasmic tail of the <chain is required for CD26-mediated signaling. Other TcR components do not replace the 5 chain.

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