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Peripheral tolerance in T cell receptor-transgenic mice: Evidence for T cell anergy

✍ Scribed by Dean Falb; Thomas J. Briner; Geoffrey H. Sunshine; Cheryl R. Bourque; Mohammad Luqman; Malcolm L. Gefter; Thomas Kamradt


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
567 KB
Volume
26
Category
Article
ISSN
0014-2980

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Antigen-specific T cell tolerance can be induced by systemic injection of high-dose antigen. In particular, a single intravenous (i.v.) injection of influenza virus hemagglutinin peptide in HNT-TCR transgenic mice induces T cell tolerance through thymocyte apoptosis as well as anergy and deletion of