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A nonredundant role for the adapter protein Shc in thymic T cell development

โœ Scribed by Zhang, Li; Camerini, Victoria; Bender, Timothy P.; Ravichandran, Kodi S.


Book ID
109923518
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
990 KB
Volume
3
Category
Article
ISSN
1529-2908

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Inhibition of T cell developmemt in thym
โœ Richard M. Siegel; Katsuyuki Yui; Drew E. Tenenholz; Ralph Kubo; Mark I. Greene ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 834 KB

We have examined the effects of the immunosuppressive drug cyclosporin A (CsA) on the phenotypic maturation of Tcells in thymic organ cultures begun at day 16 of gestation. CsA specifically inhibited the generation of cells expressing high levels of a@ TcR/CD3 complexes and a mature phenotype define