𝔖 Bobbio Scriptorium
✦   LIBER   ✦

T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct

✍ Scribed by Bernd Schlereth; Cornelia Quadt; Torsten Dreier; Peter Kufer; Grit Lorenczewski; Nadja Prang; Christian Brandl; Sandra Lippold; Kathy Cobb; Kathleen Brasky; Eugen Leo; Ralf Bargou; Krishna Murthy; Patrick A. Baeuerle


Book ID
105966883
Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
412 KB
Volume
55
Category
Article
ISSN
0340-7004

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Serial killing of tumor cells by cytotox
✍ Patrick Hoffmann; Robert Hofmeister; Klaus Brischwein; Christian Brandl; Sandrin πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 French βš– 359 KB

## Abstract Certain bispecific antibodies exhibit an extraordinary potency and efficacy for target cell lysis by eliciting a polyclonal T‐cell response. One example is a CD19‐/CD3‐bispecific single‐chain antibody construct (bscCD19xCD3), which at femtomolar concentrations can redirect cytotoxic T c

Anti-CD3-based bispecific antibody desig
✍ Brian K. Link; Sheri A. Kostelny; Michael S. Cole; William P. Fusselman; J. Yun πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 French βš– 107 KB πŸ‘ 2 views

## Anti -CD3 Ψ‹ anti-B-cell antigen bispecific monoclonal antibodies (bsAbs) can redirect T-cell-mediated lysis toward malignant B cells. Clinical trials with CD3-based bsAbs have shown toxicity in patients which is likely related to nonspecific T-cell activation and targeting. Our current studies