𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct

✍ Scribed by Löffler, A; Gruen, M; Wuchter, C; Schriever, F; Kufer, P; Dreier, T; Hanakam, F; Baeuerle, P A; Bommert, K; Karawajew, L

Book ID
110055436
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
204 KB
Volume
17
Category
Article
ISSN
0887-6924

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Serial killing of tumor cells by cytotox
Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct
✍ Patrick Hoffmann; Robert Hofmeister; Klaus Brischwein; Christian Brandl; Sandrin 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 359 KB

## Abstract Certain bispecific antibodies exhibit an extraordinary potency and efficacy for target cell lysis by eliciting a polyclonal T‐cell response. One example is a CD19‐/CD3‐bispecific single‐chain antibody construct (bscCD19xCD3), which at femtomolar concentrations can redirect cytotoxic T c

Effect of tetravalent bispecific CD19×CD
Effect of tetravalent bispecific CD19×CD3 recombinant antibody construct and CD28 costimulation on lysis of malignant B cells from patients with chronic lymphocytic leukemia by autologous T cells
✍ Uwe Reusch; Fabrice Le Gall; Manfred Hensel; Gerhard Moldenhauer; Anthony D. Ho; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 284 KB

## Abstract To develop an effective antitumor immunotherapy for B‐lineage non‐Hodgkin's lymphoma, we constructed a tetravalent tandem diabody (tanDb) specific for both human CD19 (B‐cell marker) and CD3 (T‐cell antigen). Here, we report the effective killing of malignant primary B cells from patien