## Abstract Certain bispecific antibodies exhibit an extraordinary potency and efficacy for target cell lysis by eliciting a polyclonal T‐cell response. One example is a CD19‐/CD3‐bispecific single‐chain antibody construct (bscCD19xCD3), which at femtomolar concentrations can redirect cytotoxic T c
✦ LIBER ✦
The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct
✍ Scribed by Christian Brandl; Cornelia Haas; Sandrine d’Argouges; Tanja Fisch; Peter Kufer; Klaus Brischwein; Nadja Prang; Ralf Bargou; JoAnn Suzich; Patrick A. Baeuerle; Robert Hofmeister
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 431 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0340-7004
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## Abstract To develop an effective antitumor immunotherapy for B‐lineage non‐Hodgkin's lymphoma, we constructed a tetravalent tandem diabody (tanDb) specific for both human CD19 (B‐cell marker) and CD3 (T‐cell antigen). Here, we report the effective killing of malignant primary B cells from patien