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Activation of T cells by cross-linking an anti-CD3 antibody with a second anti-T cell antibody: mechanism and subset-specific activation

✍ Scribed by Christoph Walker; Florence Bettens; Werner J. Pichler

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
852 KB
Volume
17
Category
Article
ISSN
0014-2980

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## Abstract Treatment with anti‐CD3 mAb modulates immune responses that cause type 1 diabetes and other diseases. CD8^+^ Tregs can be induced in vitro and in vivo by mAb. However, 1/3 of patients do not respond to drug therapy and in an equal proportion, anti‐CD3 mAb does not induce Tregs in vitro.