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Involvement of T3 and T8 molecules in human T cell receptor function. Anti-T3 or anti-T8 antibodies do not block the antigen-dependent activation of a subset of alloreactive cytolytic T cell precursors

✍ Scribed by Alessandro Moretta; Giuseppe Pantaleo; Maria-Cristina Mingari; Lorenzo Moretta


Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
677 KB
Volume
15
Category
Article
ISSN
0014-2980

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## Abstract Treatment with anti‐CD3 mAb modulates immune responses that cause type 1 diabetes and other diseases. CD8^+^ Tregs can be induced in vitro and in vivo by mAb. However, 1/3 of patients do not respond to drug therapy and in an equal proportion, anti‐CD3 mAb does not induce Tregs in vitro.