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Synthetically modified DNAs as substrates for polymerases

✍ Scribed by Eric T Kool

Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 161 KB
Volume: 4
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(00)00141-1

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✦ Synopsis

DNA polymerase enzymes process their natural substrates with very high specificity. Yet recent experiments have shown that these enzymes can also process DNA in which the backbone or bases are modified to a surprising degree. Such experiments have important implications in understanding the mechanisms of DNA replication, and suggest important biotechnological uses as well.

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