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Modified triphosphates of carbocyclic nucleoside analogues: Synthesis, stability towards alkaline phosphatase and substrate properties for some DNA polymerases

✍ Scribed by Natalya Dyatkina; Elena Shirokova; Fritz Theil; Stanley M. Roberts; Alexander Krayevsky

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 204 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00482-9

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✦ Synopsis

New triphosphate derivatives of carbocyclic nucleoside analogues have been synthesized and shown to be potent substrates for terminal deoxynucleotidyltransferase and/or HIV reverse transcriptase; the compounds are stable to dephosphorylation with human placental alkaline phosphatase.

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