An efficient synthesis of the left half of halichondrins B and C is reported.
Synthetic studies towards paspalicine, Part 2 : synthesis of the eastern half
β Scribed by Simon Guile; J.Edwin Saxton; Mark Thornton-Pett
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 205 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The EFGH ring segment of gambierol was synthesized from 2-deoxy-D-ribose in 40 steps. The present synthesis includes a SmI 2 -mediated reductive cyclization and a Pd-catalyzed coupling of enol triflate with a zinc bis-homoenolate as key steps.
A general synthetic route for the construction of the eastern part of the macrocyclic bastadins 4-16 is presented. The brominated biaryl ethers are synthesized using the iodonium salt method. The synthesis is accomplished within 18 steps in 15.5% overall yield.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
## Summarv: A pyranodisic homologation approach to the "eastern half' of rosaramicin is described. The synthetic plan calls for two one-carbon chain extensions, but these occur at "off-template" sites where asymmetric centers are neither destroyed nor created. However, these one-carbon displacemen