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Synthetic studies towards gambierol. Part 2: Synthesis of the EFGH ring segment

✍ Scribed by Isao Kadota; Chie Kadowaki; Hiroyoshi Takamura; Yoshinori Yamamoto


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
69 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis


The EFGH ring segment of gambierol was synthesized from 2-deoxy-D-ribose in 40 steps. The present synthesis includes a SmI 2 -mediated reductive cyclization and a Pd-catalyzed coupling of enol triflate with a zinc bis-homoenolate as key steps.


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ChemInform Abstract: Synthetic Studies T
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