A sequence involving a modified Knoevenagel-Stobbe pyridine synthesis, and an unusual intramolecular reaction between a quinone and an azide, permits expeditious assembly of the ring system of the cystodytin alkaloids.
Synthetic Studies Towards Congeners of Phomactin A. Reexamination of the Structure of Sch 49028.
β Scribed by John W. C. Cheing; William P. D. Goldring; Gerald Pattenden
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 191 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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π SIMILAR VOLUMES
A synthesis of the C9-C23 subunit of the group A streptogramin antibiotics is described. The synthesis incorporates a palladium-catalysed sp-sp coupling and a catalytic asymmetric vinylogous Mukaiyama aldol reaction to induce the stereogenic centre at C14.
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