An advanced ring-closing metathesis precursor for the synthesis of the marine macrolide neopeltolide is prepared in a stereocontrolled manner by the coupling of the C2-C10 and C11-C16 subunits. The metathesis reaction of 4 with Grubbs' II or Nolan's indenylidene catalyst led to the unexpected format
Synthetic Studies Toward Sarain A (I). Formation of the Western Macrocyclic Ring.
β Scribed by Moo Je Sung; Hyoung Ik Lee; Hee Bong Lee; Jin Kun Cha
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 56 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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A general synthetic route for the construction of the western part of the macrocyclic bastadins 4-16 is presented. The western and the eastern segments were coupled using the imidazolide of the corresponding acid. The bromine at position y2 may be added at this advanced step regiospecifically, stren
## Abstract A novel cyclopentenone ring annelation reaction is described. The treatment of the nitro compound **13** with aqueous sodium hydroxide in the presence of a phaseβtransfer catalyst furnished **14a** in one step. Similar treatment of **7** led to **8**, the reaction of which with __t__βBu