✦ LIBER ✦

Studies towards the synthesis of neopeltolide: synthesis of a ring-closing metathesis macrocyclization precursor

✍ Scribed by Gordon J. Florence; Romain F. Cadou

Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 445 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.08.118

No coin nor oath required. For personal study only.

✦ Synopsis

An advanced ring-closing metathesis precursor for the synthesis of the marine macrolide neopeltolide is prepared in a stereocontrolled manner by the coupling of the C2-C10 and C11-C16 subunits. The metathesis reaction of 4 with Grubbs' II or Nolan's indenylidene catalyst led to the unexpected formation of cycloheptene 18.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Macroc

ChemInform Abstract: Synthesis of Macrocyclic Compounds by Ring-Closing Metathesis

✍ K. C. Majumdar; H. Rahaman; B. Roy 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 15 KB 👁 2 views

Synthesis of Resorcinylic Macrocycles Re

Synthesis of Resorcinylic Macrocycles Related to Radicicol via Ring-Closing Metathesis.

✍ Tracey S. Cooper; Butrus Atrash; Peter Sheldrake; Paul Workman; Edward McDonald 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views

Synthesis of macrocyclic lactams and lac

Synthesis of macrocyclic lactams and lactones via ring-closing olefin metathesis

✍ William P.D. Goldring; AndréS. Hodder; Larry Weiler 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 254 KB

## A&Wrack Lactones and lactams 4-6 were synthesized from a series of acyclic dienes 1-3 via ringclosing olefin metathesis, as shown in equation 1. The geometry of the resulting double bond was determined, and the UZratios compared to values from molecular mechanics calculations.

Synthesis of bruguierol A employing ring

Synthesis of bruguierol A employing ring closing metathesis

✍ Debayan Sarkar; Ramanathapuram V. Venkateswaran 📂 Article 📅 2011 🏛 Elsevier Science 🌐 French ⚖ 273 KB

Application of ring closing metathesis i

Application of ring closing metathesis in efficient synthesis of macrocyclic crown compounds

✍ Yehia A. Ibrahim 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 751 KB

RCM of suitable ␣,-dienes led to efficient atom economic synthetic approaches towards azacrown ether derivatives with 8-40 membered ring sizes.

Macrocyclization by Ring-Closing Metathe

Macrocyclization by Ring-Closing Metathesis in the Total Synthesis of Natural Products: Reaction Conditions and Limitations

✍ Ana Gradillas; Javier Perez-Castells 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 11 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.