Synthesis of macrocyclic lactams and lactones via ring-closing olefin metathesis

✍ Scribed by William P.D. Goldring; AndréS. Hodder; Larry Weiler

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 254 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00966-6

✦ Synopsis

A&Wrack

Lactones and lactams 4-6 were synthesized from a series of acyclic dienes 1-3 via ringclosing olefin metathesis, as shown in equation 1. The geometry of the resulting double bond was determined, and the UZratios compared to values from molecular mechanics calculations.