## Abstract For Abstract see ChemInform Abstract in Full Text.
Synthetic studies towards phomactin A. Concise synthesis of the novel tricyclic furanochroman system
โ Scribed by Kevin M. Foote; Christopher J. Hayes; Gerald Pattenden
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 192 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
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ML-3000 was obtained from l-chloro-3-phenyl-2-propyne in 8 steps with an overall yield of 19%. The key steps are a thermal acid-promoted bicyclization of an ยขo-acetylenic amino ester and a Suzuki cross-coupling reaction between a heteroaryl triflate and (4-chlorophenyl)boronic acid.
A sequence involving a modified Knoevenagel-Stobbe pyridine synthesis, and an unusual intramolecular reaction between a quinone and an azide, permits expeditious assembly of the ring system of the cystodytin alkaloids.