✦ LIBER ✦
Synthetic studies towards ML-3000 a concise synthesis of this non-steroidal anti-inflammatory drug
✍ Scribed by Janine Cossy; Damien Belotti
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 625 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
ML-3000 was obtained from l-chloro-3-phenyl-2-propyne in 8 steps with an overall yield of 19%. The key steps are a thermal acid-promoted bicyclization of an ¢o-acetylenic amino ester and a Suzuki cross-coupling reaction between a heteroaryl triflate and (4-chlorophenyl)boronic acid.